Calm=One

Do you know that anxiety is socially contagious?

Studies suggest that anxious children and adults can trigger anxiety in peers and family members, too.

How CalmOne® supports you and your child’s health*

When you or your child experience the emotions of anxiety and fear in response to actual or imagined threats, the demand for certain nutrients increases.


They are required to support the physical stress of the negative emotions, healthy functioning of the immune system, and your child’s normal growth and development.

CalmOne is targeted to support these increased nutritional requirements

and by doing so, helps you and your child meet challenges with resilience — the ability to bounce back.*

EPIFOLIN®

Essential Bioavailable B-Vitamins

Epifolin® is a key complex in all BRILLIANT® Health Products.

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Essential Bioavailable B-Vitamins

Epifolin® is a key complex in all BRILLIANT® Health Products.

Epifolin®’s essential bioavailable methylated B-Vitamins are critical for supporting early brain growth and development. They are one carbon metabolic co-factors that modulate gene expression and support DNA, RNA, chromatin and proper cell division in adults and children.

AMINO ACIDS

The amino acids in Calm≈One support HPA Axis regulation and the Gut/Brain connection.

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The amino acids in Calm≈One support HPA Axis regulation and the Gut/Brain connection.

They are critical to reducing the effects of the stress hormones, cortisol and adrenalin as well as the excitatory neurotransmitter, nor-epinephrine. The amino acids also provide key nutrients for the synthesis of inhibitory neurotransmitters that work to calm and relax.

PHYTONUTRIENTS & PHOSPHOLIPIDS

The phytonutrients and phospholipids in Calm≈One have multiple functions overlapping and complementing other ingredients in the formula.

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The phytonutrients and phospholipids in Calm≈One have multiple functions overlapping and complementing other ingredients in the formula.

They are needed for brain development and growth, maintenance of RNA, DNA and proper cell division. They are anti-inflammatory, antioxidant and support the immune system and Phase II liver detox. They are specifically helpful with anxiety because they support the HPA Axis regulation, the Gut/Brain connection, muscle relaxation, cell signaling, reduce the effects of stress hormones and support the synthesis of calming neurotransmitters.

CHELATED
MINERAL

The chelated mineral, Boron, serves multiple purposes.

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The chelated mineral, Boron, serves multiple purposes.

It supports the immune system and boosts Phase II liver detoxification. In addition, it is anti-inflammatory and antioxidant.

Genetic factors can affect anxiety in adults and children

Ongoing research indicates that anxiety and fear is often intergenerational and linked to genes that impact the processing of specific hormones and neurotransmitters. If you or your child are anxious, there may be others in the family for whom this is true, as well.

Lifestyle and environmental factors can also affect anxiety

These factors include diet, physical activity, health problems, social isolation, bullying and hostile social relationships, changing hormone levels, excessive screen time, disrupted daily routines, seasonal and weather changes, environmental and food toxins, relocation, traumatic experiences, and illness, divorce or death in the family.

Many of these influences and events are out of your control but CalmOne can help both you and your child’s response to these challenges.*

Long-term impacts of anxiety and fear

Chronic or extreme anxiety and fear negatively impact a range of body systems and processes, resulting in both short and long-term psychological and physiological harm to adults and children. 

The following are important ways that adults and children can be negatively impacted.


BRAIN AND
NERVOUS SYSTEM

Anxiety has been shown to interfere with brain-cell communication both short term and over time.

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Anxiety has been shown to interfere with brain-cell communication both short term and over time. Long term, chronic anxiety can result in the degradation of astrocytes, the brain cells that regulate neuronal communication. This degradation can increase the risk of neuropsychiatric disorders, including depression, drug addiction, and dementias.


LEARNING AND MEMORY

Anxiety will not only make adults and children uncomfortable in their environment, but it will distract them from the opportunity to learn and participate.

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Anxiety will not only make adults and children uncomfortable in their environment, but it will distract them from the opportunity to learn and participate.

Anxiety affects working memory, a core cognitive function that enables the retention of information in the mind for the period of time required to do something with it.

Anxiety also makes thought processing less efficient, as well as causes both adults and children to avoid engaging in social and learning opportunities.

GROWTH AND DEVELOPMENT

Chronic and high levels of anxiety negatively affect behavioral and emotional development.

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Chronic and high levels of anxiety negatively affect behavioral and emotional development.

The anxious child can end up avoiding opportunities for social interactions and development of motor skills, resulting in further anxiety because of lower self-perceived peer acceptance and competence.

Negative health impacts of chronic and high levels of anxiety can persist into adulthood, increasing the risk of depression, fatigue, weight gain, high blood pressure, heart disease and stroke.


NEUROENDOCRINE SYSTEM

The Hypothalamus-Pituitary-Adrenal (HPA) Axis is the body’s central stress response system.

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The Hypothalamus-Pituitary-Adrenal (HPA) Axis is the body’s central stress response system. It connects the Central Nervous System and the Endocrine System in order to help both adults and children adapt to changes in routine, weather, health, diet, work, school, home, social life, personal losses or the introduction of something new or unwelcome. Anxiety and fear signal the Hypothalamus-Pituitary-Adrenal (HPA) Axis to produce stress hormones which negatively impact the brain and behavior, both short and long term.


DIGESTION

Anxiety and fear trigger increased production of stress hormones, some of which enter the digestive tract...

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Anxiety and fear trigger increased production of stress hormones, some of which enter the digestive tract, creating inflammation of the gut lining, negatively impacting the gut flora (microbiome) and decreasing antibodies.

In turn, the nervous system of the disturbed gut (the Enteric nervous system) signals the Central Nervous System through the Gut/Brain Axis and triggers increased production of excitatory neurotransmitters in the brain. This creates a feedback loop, perpetuating the anxiety and fear.


IMMUNE SYSTEM
AND INFLAMMATION

Increased production of stress hormones creates inflammation in the lining of the gut...

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Increased production of stress hormones creates inflammation in the lining of the gut, upsetting the balance of microorganisms and reducing the production of antibodies by the immune system.

In recent years, a great deal of attention has been given to studying the effect of emotional stress on the microbiome and conversely, the effect of the microbiome on the emotions.


EPIGENETICS

Even though chronic anxiety is considered moderately heritable, researchers conducting genome-wide association studies have not identified specific genes causing anxiety.

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Even though chronic anxiety is considered moderately heritable, researchers conducting genome-wide association studies have not identified specific genes causing anxiety.

This suggests that environmental factors and the epigenome play active roles in individual susceptibility to stress and the resulting experience of anxiety. Strong evidence of epigenetic control of the HPA Axis and stress-responsive areas of the brain has been found in animal studies of anxiety-related disorders.


STRESS RESILIENCE

When self-regulation is disrupted by stress hormones, the process of adaptation to life’s challenges is negatively impacted.

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When self-regulation is disrupted by stress hormones, the process of adaptation to life’s challenges is negatively impacted. This means that the child or adult who is confronted with adversity, trauma, threats and tragedy has a harder time returning to homeostasis (normal functioning) and balance. If adequate nutritional support for the neurobiological mechanisms (neural circuits and pathways) designed to help handle stresses is lacking, the system lacks resilience— the capacity to bounce back, recover from the challenges and carry on.

The power and uniqueness of CalmOne


comes from how well the ingredients directly and indirectly support the cells and pathways impacted by anxiety and fear.*

Selected reference studies


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Becquet D, Hery M, Francois-Bellan AM, Giraud P, Deprez P, Faudon M, Fache MP, Hery F. Glutamate, GABA, glycine and taurine modulate serotonin synthesis and release in rostral and caudal rhombencephalic raphe cells in primary cultures. Neurochem Int. 1993 Sep;23(3):269-83. doi: 10.1016/0197-0186(93)90118-o. PMID: 7693110

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El Idrissi A, Trenkner E. Taurine as a modulator of excitatory and inhibitory neurotransmission. Neurochem Res. 2004 Jan;29(1):189-97. doi: 10.1023/b:nere.0000010448.17740.6e. PMID: 14992278.

Gentile, Francesco et al. “Diet, Microbiota and Brain Health: Unraveling the Network Intersecting Metabolism and Neurodegeneration.” International journal of molecular sciencesvol. 21,20 7471. 10 Oct. 2020, doi:10.3390/ijms21207471

Ghosh, Dilip ed. Role of food or food component in brain health. Nutraceuticals in Brain Health and Beyond. Academic Press 2021 3-13. ISBN 9780128205938, https://doi.org/10.1016/B978-0-12-820593-8.00002-1.

Glutamate, GABA, glycine and taurine modulate serotonin synthesis and release in rostral and caudal rhombencephalic raphe cells in primary cultures. Neurochemistry International, 1993 Volume 23, Issue 3, Pages 269-283. ISSN 0197-(http://www.sciencedirect.com/science/article/pii/019701869390118O)

Gomez-Ramirez M, Kelly SP, Montesi JL, Foxe JJ. The effects of L-theanine on alpha-band oscillatory brain activity during a visuo-spatial attention task. Brain Topogr. 2009 Jun;22(1):44-51. doi: 10.1007/s10548-008-0068-z. Epub 2008 Oct 9. PMID: 18841456.

He Y, Ouyang J, Hu Z, Yang J, Chu Y, Huang S, Yang Y, Liu C. Intervention mechanism of repeated oral GABA administration on anxiety-like behaviors induced by emotional stress in rats. Psychiatry Res. 2019 Jan;271:649-657. doi: 10.1016/j.psychres.2018.12.025. Epub 2018 Dec 5. PMID: 30791338.

Hidese S, Ogawa S, Ota M, Ishida I, Yasukawa Z, Ozeki M, Kunugi H. Effects of L-Theanine Administration on Stress-Related Symptoms and Cognitive Functions in Healthy Adults: A Randomized Controlled Trial. Nutrients. 2019 Oct 3;11(10):2362. doi: 10.3390/nu11102362. PMID: 31623400; PMCID: PMC6836118.

Jakaria M, Azam S, Haque ME, Jo SH, Uddin MS, Kim IS, Choi DK. Taurine and its analogs in neurological disorders: Focus on therapeutic potential and molecular mechanisms. Redox Biol. 2019 Jun;24:101223. doi: 10.1016/j.redox.2019.101223. Epub 2019 May 21. PMID: 31141786; PMCID: PMC6536745.

K. Kobayashi et al., “Effects of L‑Theanine on the Release of Alpha-Brain Waves in Human Volunteers,” Journal of the Agricultural Chemical Society of Japan 72, no. 2 (1998): 153–157.

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Lopes Sakamoto F, Metzker Pereira Ribeiro R, Amador Bueno A, Oliveira Santos H. Psychotropic effects of L-theanine and its clinical properties: From the management of anxiety and stress to a potential use in schizophrenia. Pharmacol Res. 2019 Sep;147:104395. doi: 10.1016/j.phrs.2019.104395. Epub 2019 Aug 11. PMID: 31412272.

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McCoy CR, Jackson NL, Day J, Clinton SM. Genetic predisposition to high anxiety- and depression-like behavior coincides with diminished DNA methylation in the adult rat amygdala. Behav Brain Res. 2017 Mar 1;320:165-178. doi: 10.1016/j.bbr.2016.12.008. Epub 2016 Dec 11. PMID: 27965039; PMCID: PMC5239722.